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In adjusted analyses, a lower hazard was seen for GLP-1 receptor agonists, but the overall signal was far less dramatic than in the insulin/metformin comparison

Rarely, a developing fetus with preexisting liver disease can develop neonatal hemochromatosis

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If worsening of or failure to achieve adequate glycemic control occurs, consider alternative antidiabetic therapy Hypersensitivity Reactions Reports of serious hypersensitivity reactions (eg, anaphylaxis and angioedema)