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These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism

This helped to show that NNMT is a key target in metabolic research. Neelakantan and colleagues then expanded research involving small-molecule NNMT inhibitors

This makes it particularly effective for patients with absorption problems such as pernicious anaemia

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For example, heavy rainfall can leach cobalt from the topsoil and make it more difficult for it to be available to grazers