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DIRECTIONS FOR FUTURE RESEARCH OF GHRELIN RECEPTOR AGONIST AND POTENTIAL THERAPY LIMITATIONS: Potential use of relamorelin and other agonists in FD and NERD refractory to PPI Indisputably, the majority of studies presented in this paper support the notion that the small molecule ghrelin and GRLR-R agonists may offer a well-integrated therapeutic option for the management of various hypomotility disorders, especially gastroparesis ( Table 2 )

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