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Shown below on the left is GLP-1 binding to the GLP-1 receptor, PDB 6B3J

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Furthermore, GLP-1RAs can counteract the diabetes-induced downregulation of the glutamate-aspartate transporter (GLAST), a key glial transporter responsible for clearing extracellular glutamate [57]

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo