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First: the lipolytic effect in animal models (in rats and mice on a high-fat diet) did not translate to humans with stabilized obesity

Synthesized peptides have been used in medicine as pharmaceuticals for decades, says endocrinologist Rekha Kumar, MD, associate professor of clinical medicine at Weill Cornell Medicine in New York City

[cited 2024 Feb

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Doctors often start with daily or weekly doses for a few weeks

Concern about excessive intake and potential adverse effects of folic acid in addition to other health outcomes has been the subject of NIH-sponsored workshops and meetings of experts (88, 89)