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Here are some caveats: I am NOT a doctor and I don't play one on the internet

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Our study found that chronic hypoxia promoted HIF-2 rather than HIF-1 entry into the nucleus, and nucleation of HIF-2 resulted in transcriptional expression of Acer2, a newly discovered downstream target of HIF that was reported in adipocytes [19, 24]

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Sclerostin, encoded by the SOST gene, is secreted by osteocytes and suppresses bone formation

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Ma Y, Deng Y, Li N, Dong A, Li H, Chen S, et al

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10:e0121204

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