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Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage

10.1113/expphysiol.1997.sp004024 103 SiesH

Limit alcohol intake and avoid smoking, as both rapidly deplete glutathione reserves and increase oxidative stress

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Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells

Additionally, many intracellular or latent fungal cells can enter a dormant state, resulting in downregulation of drug targets, reduced membrane permeability, and decreased susceptibility to treatment (Uribe-Querol and Rosales, 2020)