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Table of Contents Why You Might Gain Weight Despite Eating in a Calorie Deficit Inaccurate calorie tracking, metabolic adaptation, and temporary water retention from exercise or dietary changes are the most common reasons the scales rise or stall despite a calorie deficit

In my experience reviewing the Phase 2 trial data, the appetite reduction is noticeable early, but the scale does not move much yet

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There are two reasons that make these solutions non-viable

Antimicrobial peptides exemplify direct cellular interaction mechanisms

and the new nonpeptide GLP-1, orforglipron (Foundayo)