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1 Introduction The human gut is a fascinating ecosystem that harbors trillions of microorganisms collectively known as gut microbiota that play a crucial role in several physiological functions through their derived metabolites such as nutrient metabolism, immune system regulation, vitamin production, mental health, and brain function that contribute to overall maintaining of health

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In line with a previous study by the authors, the rifaximin-mediated blunting of intestinal hyperpermeability suppressed the CDAA-induced hepatic proinflammatory response and fibrogenesis by inhibiting hepatic the LPS/TLR4 signaling pathway (23)