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Cardiovascular Outcomes with Retatrutide: Interim Analysis

Using bulk RNA-sequencing data, we found that lower expression of mevalonate decarboxylase ( MVD ), mevalonate kinase ( MVK ), farnesyl diphosphate synthase ( FDPS ), and farnesyl diphosphate farnesyltransferase 1 ( FDFT1 ) was independently associated with improved survival (Figure 1CD)

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This gradual titration allows your body to adapt to the medication whilst your healthcare team monitors your response

10.1101/gr.096651.109 Genome Res

A recent meta-analysis including data from SURMOUNT-1, a trial conducted in individuals with obesity, confirmed the favorable effects of tirzepatide on dyslipidemia, finding a 16 and 13.7% change from baseline in triglycerides and very low-density lipoproteins with tirzepatide 15 mg vs