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The inclusion complex exhibited no toxicity towards normal neuronal cells [177]

When autophagy was prevented, GSTP1-induced ADR resistance reduced

For instance, oxidative stress disrupts redox-sensitive organelles, including the endoplasmic reticulum (ER) [9], leading to the accumulation of misfolded proteins, which triggers ER stress and impairs protein folding, modification, and transport [10]

Two significant checkpoints are the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway and T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3)

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The k red value of 1.4 10 6 M 1 s 1 for PfGrx C88S (SH) 2 is about two orders of magnitude higher than the highest k ox value for PfGrx C32S/C88S (SSG) in accordance with a physiological relevance of glutaredoxins as deglutathionylating enzymes