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It also contributes to blood pressure and autonomic cardiovascular regulation, enhancement of immune function, and reduction of inflammation in the gastrointestinal tract

GIPR antagonism and Gipr hypo-KO also sensitise to cagrilintide-induced weight loss

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11.1 +/- 1.1% with pramlintide + sibutramine, 11.3 +/- 0.9% with pramlintide + phentermine, -3.7 +/- 0.7% with pramlintide