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MR: Writing original draft, Methodology, Investigation, Supervision

Rui L, Yuan M, Frantz D, Shoelson S, White MF

Protective action of the peroxisome proliferator-activated receptor- agonist pioglitazone in a mouse model of Parkinson's disease

GH promotes lipolysis, particularly in visceral adipose tissue, which is metabolically distinct from subcutaneous fat in its sensitivity to GH-driven lipolysis

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This finding was significant enough that the tirzepatide drug label now advises patients using oral hormonal contraceptives to switch to or add a non-oral contraceptive method when initiating tirzepatide and after each dose escalation