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In 56-week clinical trials, patients taking Contrave with diet and exercise lost an average of 5-9% of their body weight, compared to 1-5% with placebo

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Millions of people use it safely

The table below highlights some key differences between these medications

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Restarting before this window closes means building on suppressed receptor sensitivity, which requires 20-30% higher doses for equivalent effect and accelerates tolerance development over multiple cycles