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Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine

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It also notes that onset typically coincides with dose escalation phases rather than appearing later out of nowhere

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Therefore, some clinicians might look into L-Arginine supplementation in patients requiring cardiovascular support, although this would be under strict supervision due to the potential risk of significant hypotension or interactions with cardiovascular medications