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Finally, some sensitive individuals may experience mild gastrointestinal upset, such as diarrhea or cramping, when first introducing 5-HTP, simply because the gut is rapidly waking up from a paralyzed state

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The isosteric replacement of sp 2 -heavy aromatic rings with sp 3 -rich small-ring cage hydrocarbon systems has emerged as a promising strategy towards improving the physicochemical and pharmacokinetic properties of drug candidates 25,26

The potential therapeutic role of the melatoninergic system in treatment of epilepsy and comorbid depression

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