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10.2337/db17-1150 14

It effectively sequesters unbound copper from amyloid-beta complexes, reducing metal-induced neurotoxicity, protein aggregation, and reactive oxygen species generation in CNS tissue

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AOD-9604 also inhibits lipogenesis, the synthesis of new fat, adding a second metabolic angle

demonstrated that different levels of ROS act upstream of signalling pathways in a threshold-dependent manner to dictate the type of response required 122

In total, ~15-20% of patients with AA and 2-6% of patients with PNH were found to to develop secondary MDS/AML by 10 years of follow-up