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Safer, evidence-based alternatives include topical treatments (retinoids, vitamin C, niacinamide, hydroquinone under supervision), oral antioxidants, strict sun protection, and lifestyle measures

Adverse Reactions Adverse reactions commonly associated with Tresiba are hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, pruritus, rash, edema, and weight gain

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And UC is believed to result from the interaction between genetic susceptibility, immune factors, and gut microbiota alteration, leading to abnormal mucosal immune responses and impaired epithelial barrier function