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You see, this black box warning was ultimately put in place based on animal studies, and what researchers found is that when rodents were exposed to GLP-1 RAs such as Ozmepic, the rodents developed MTC

Several authors disclosed ties to biopharmaceutical companies, including Novo Nordisk, which manufactures semaglutide and funded the study

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Materials availability All data generated or analyzed during this study are included in this published article (tables and figures)

If you came here looking specifically for the cardarine angle, the mechanism contrast is: SLU-PP-332 (ERRs, transcriptional, no published carcinogenicity studies), MOTS-c (AMPK, kinase, mitochondrial peptide), cardarine (PPAR, transcriptional, rodent carcinogenicity flag )