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Orally administered geniposide and its iridoid analogs exhibit antinociceptive effects in the formalin-induced tonic flinching response via activation of spinal GLP-1Rs, potentially targeting the same binding sites as exendin (939) and exenatide [33]

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25 The Val 23 and Ile 27 used in tirzepatide are likely to have little impact on either GLP-1 or GIP activity because they are the same kind of residue and no specific interaction in these sites has been detected