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There are two key hormones involved: Glucose Dependant Insulinotropic Polypeptide or GIP and Glucagon like Peptide #1 or GLP-1

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doi: 10.1074/jbc.M111.310342 28 KosiborodMNAbildstrmSZBorlaugBAButlerJRasmussenSDaviesMet al

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This is because obesity is a major risk factor for numerous health conditions, including heart disease, stroke, high blood pressure and at least 13 different types of cancer, according to the Centers for Disease Control and Prevention

And all of these improvements will of course also have an effect to dampen inflammation