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J Neuroimmune Pharmacol 19, 36 (2024)

PCO-02 Safety and pharmacokinetics trial (Clinical Trial No

Importantly, Table 3 presents a summary of important GLP-1 trials that focus on aging-related outcomes

The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9

doi: 10.23736/S2724-5683.22.05900-2

A vial used at higher doses will be depleted faster, potentially well within the BUD, while a vial used at lower titration doses may approach the BUD before all doses are drawn