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Cyclophosphamide, a nitrogen mustard, induces GPX4 degradation and activates AIFM1, leading to parthanatos in leukemia cells [155]

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FOXO4-DRI vs nearby senolytics Option FOXO4-DRI Type D-retro-inverso peptide Human trial stage None (preclinical only) Option Dasatinib + Quercetin (D+Q) Type Small-molecule drug + flavonoid Human trial stage Early human trials (e.g., Alzheimer's) Option Navitoclax Type BCL-2 family inhibitor Human trial stage Later-stage trials (e.g., myelofibrosis) D+Q and navitoclax are further along in humans but can affect healthy cells (e.g., low platelets)

One compound that has caught attention is GHK-Cu, a naturally occurring copper peptide widely used in skin and hair formulations

Treatment duration depends heavily on the dogs condition, response, and vet guidance