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For example, AS involves the toxic accumulation of lipids in vessel walls, and in AS-related cells, such as macrophages, vascular smooth muscle cells, and endothelial cells, GPX levels are low, iron metabolism is dysregulated, and ROS are elevated [13, 14]

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Rather than acting through a single well-defined receptor, DSIP appears to influence multiple signaling systems, including stress-response and sleep-regulatory networks