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Vitamin C provision improves mood in acutely hospitalized patients

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In acute overdose or when the maximum daily dose is exceeded over a prolonged period, metabolism by conjugation becomes saturated, and excess APAP is oxidatively metabolized by the CYP enzymes 2E1, 1A2, 2A6, and 3A4 to the hepatotoxic reactive metabolite N -acetyl- p -benzoquinone imine (NAPQI)

[2] Causes are usually related to conditions that give rise to malabsorption of vitamin B 12 , particularly autoimmune gastritis in pernicious anemia

PLoS One doi:10.1371/JOURNAL

in particular, those with smaller testicular volume and decreased testicular blood flow