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The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle primum non nocere (Micallef et al., 2020a)

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Obesity in adults: a clinical practice guideline

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The responsible clinical approach is to titrate slowly, evaluate response at each stage with monitoring, and stop increasing when results are adequate rather than when the theoretical maximum has been reached