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Mechanistic studies in mice indicate that IL-17 contributes to hepatic inflammation by inducing CXCL10-dependent macrophage accumulation and enhancing collagen secretion by HSCs via STAT3-dependent pathways (119122)

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Arrows added in purple to show the direction of gene changes for key enzymes involved in this pathway following melatonin treatment

Variglobin) with standard and immunofluorescent microscopy and demonstrated fibrin deposition on the sclerosed veins only

Possible Side Effects: Occasional mild injection-site reactions (redness, itching)