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Am J Physiol Heart Circ Physiol 289:H2649-2656 Uncini A, Eleopra R, Onofrj M (2015) Polyneuropathy associated with duodenal infusion of levodopa in Parkinsons disease: features, pathogenesis and management
Joyner, 1964
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Oral L-carnitine has lower bioavailability than injectable forms (approximately 15-25% absorption versus near-complete absorption for injectables), which is why oral doses need to be higher
For efficacy outcomes, in case trials reported results for different estimand analyses, we preferably extracted data for the efficacy estimand, which represents on-treatment efficacy without the influence of rescue therapy [14]
repletion reverses hematologic symptoms within days and neurologic sequelae over weeks, reflecting differential tissue turnover
