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Montesano, M

Milk thistle extract (80240 mg/day) was given orally to the treatment group during a 56-day double-blind research in children with acute lymphoblastic leukemia (ALL) and liver toxicity, and silymarin was found to reduce the frequency of hepatic toxicity in ALL chemotherapy regimens

et al., 2022) and can be influenced by the tumor suppressor protein p53 in response to DNA damage (Wada et al., 2018)

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Released Cyt C activates the caspase cascade, particularly caspase-3, leading to apoptosis (Zhu et al., 2016)

Helzlsouer KJ, Selmin O, Huang H-Y, Strickland PT, Hoffman S, Alberg AJ, Watson M, Comstock GW, Bell D