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Effect of Combination Therapy on Metabolic Outcomes Based on a 2019 meta-analysis of seven randomised controlled trials (1,913 participants) with a primary duration ranging from 12 to 30 weeks, co-administration of SGLT-2 inhibitors and GLP-1 receptor agonists had a less than additive effect on HbA 1c and body weight and an additive reduction in systolic blood pressure compared with each monocomponent without increasing risk of hypoglycaemia [5]

Ajabnoor GMA, Hashim KT, Alzahrani MM, Alsuheili AZ, Alharbi AF, Alhozali AM, Enani S, Eldakhakhny B, Elsamanoudy A

What does clinical evidence say about long-term weight maintenance after GLP-1 therapy stops

To sum up, current data suggests that semaglutide does not significantly increase the risk of complications during a colonoscopy

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