Asad Niazi (MD) Doctor of Medicine (MD), Internal Medicine Physician Looking for weight-loss solutions
For glutathione, bioavailability is the primary concern
Tesofensine , a triple monoamine reuptake inhibitor, showed significant weight loss in Phase 2 trials through appetite suppression and increased metabolic rate
Oxidative Imbalance and Reduced GR Function Several specific scenarios create conditions where hydrogen water's mechanism may provide advantages over relying solely on GR-mediated glutathione recycling: NADPH deficiency states : Conditions that compromise NADPH production, such as glucose-6-phosphate dehydrogenase deficiency, metformin therapy, or severe caloric restriction, limit GR function due to insufficient cofactor availability
Moreover, modified leptin release from adipose tissue, characteristic of obesity, results in leptin resistance and diminished leptin sensitivity, further disrupting hypothalamic-pituitary regulation
Weight reduction should be gradual (0.51 kg weekly) to avoid rapid mobilisation of fat, which paradoxically may worsen liver inflammation
