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However, changes in appetite and digestion are not the only effects Semaglutide can have on the body

Large meals overwhelm an already-slowed stomach

Retatrutide also remains investigational, with ClinicalTrials.gov listing active or recently updated Phase 3 research records as of May 2026

Aesthet Surg J 2022

Seven day exercise logs and three day dietary recall logs were completed by all subjects to provide verification of the consistency of training and diet

Clinical trial dosing protocol Phase 2 and Phase 3 trials used a titration approach, starting at lower doses and increasing gradually to minimize gastrointestinal side effects