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Crucially: all AEs (with the exception of transient urticarial rashes) were more common at higher doses (125 or 250 mcg/kg) which is precisely why the authors singled out 30 and 60 mcg/kg as the better-tolerated doses

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It is assumed that the dose should cover the entire daily requirement alone

10.1186/s40035-019-0174-8 146 MarkesberyW

The Lipooligosaccharide of the gut symbiont Akkermansia Muciniphila exhibits a remarkable structure and TLR signaling capacity