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A novel, multitargeted endogenous metabolic modulator composition impacts metabolism, inflammation, and fibrosis in nonalcoholic steatohepatitis-relevant primary human cell models

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Preclinical investigations have demonstrated that selective probiotic supplementation, particularly with Lactobacillus and Bifidobacterium species, or prebiotic administration, effectively restores microbial homeostasis, enhances colonic short-chain fatty acid (SCFA) production, and subsequently inhibits the TGF-1/Smad3 signaling pathway in the kidneys (15)

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