CREB activation is linked to neural plasticity and the therapeutic effects of antidepressants, whereas NF-B activation is associated with inflammatory responses and may exacerbate depressive symptoms [367, 368]
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PLoS One 13 (2), e0192252
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By regulating and slowing melanin synthesis, it effectively reduces the appearance of dark patches, discoloration, spots, tanning, and uneven skin tone and prevents them from reappearing