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Although the underlying mechanism remains elusive, ferroptosis exhibits several distinctive features: Alterations in cell morphology are prominent during ferroptosis, characterized by reduced mitochondrial size, increased membrane density, diminished or absent mitochondrial cristae, and potential disruption of the outer membrane
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Yilmaz M, Muftuoglu M, Kantarjian H, DiNardo CD, Kadia TM, Konopleva M, Borthakur G, Pemmaraju N, Short NJ, Alvarado Y, Maiti A, Masarova L, Montalban-Bravo G, Jurisprudencia C, Pike AM, Loghavi S, Patel K, Tang G, Matthews JA, Kornblau SM, Jabbour EJ, MD, Garcia-Manero G, Ruvolo V, Ravandi F, Andreeff M , Daver N