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405 Proteasome inhibitors Although proteasome inhibition is generally associated with toxicity, low-dose inhibition has been explored as a strategy to induce compensatory autophagy
This occurs because alcohol inhibits hepatic gluconeogenesisthe liver's ability to produce glucosewhich can be problematic for individuals with diabetes, especially those taking glucose-lowering medications
While this study did not seek to identify biomarkers related to injury progression and recovery, it is important in that it demonstrated the critical role of bile acids in APAP-induced liver injury
A non-normal distribution was assumed and therefore Wilcoxon matched-pairs signed rank test was used for sample size calculation
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