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Statements Data availability statement The data generated in this study can be found in ProteomeXchange: Ethics statement The animal study was reviewed and approved by Animal handling and experimentation were approved by the Laboratory Animal Care and Use Committee of the Shaanxi University of Chinese Medicine

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In the present study, the number of freezing behaviors was more evident in the animals submitted to shocks, suggesting that fear and conditioned stress were successfully induced

There is a wide range of MRS sequences available to measure in vivo brain GSH, and while the current studies in AD and MCI suggests that MEGA-PRESS is a good candidate for technique standardization, recent advances in MEGA-PRESS have also allowed for simultaneous measurements of pairs of compounds such as GSH/-aminobutyric acid and N -acetyl aspartate/ N -acetyl aspartyl glutamate in one acquisition [96, 97]

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