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Notably, metabolic benefits often diminish after treatment discontinuation [116], underscoring the importance of long-term planning in therapeutic decision-making

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Innovative analytical approaches with stratification by individual-level characteristics (for example, obesity, ethnicity, GDM severity and so on) and treatment regimens (diagnostic criteria, treatment timing and follow-up duration) are needed to establish efficacy across a range of end points and to identify which, if any, subgroups might benefit from metformin treatment during pregnancy

This allows athletes to sustain peak performance for more extended periods