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Additionally, NAD+ has a huge role to play in Glutathione synthesis

[1] [12] For most people, doses up to 2 mg (2000 micrograms) daily are unlikely to cause harm according to NHS guidance, as B12 is water-soluble and excess is typically excreted in urine

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Some researchers adjust dosing based on body weight, using approximately 30 to 50mcg of total KLOW per kilogram of body weight as a rough target for moderate dosing