Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance
161, 166, 167 Alkalinization increases urothelial penetration of lidocaine and therefore is expected to improve efficacy, but it also can increase systemic absorption and potential toxicity
The authors reported a 39% improvement in the TWSTRS (i.e., Toronto Western Spasmodic Torticollis Rating Scale) score and a 40% improvement in the quality of life questionnaires from one toxin injection to the other (12 weeks, 20 mixed-site stimulation sessions) without any other neurophysiological change
This has lead to the use of alternate velocity equations which do not use the kinetic constants kcat and Km at all, instead depending on a different rate constant, (Toppo et al., 2009)
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Journal of Strength and Conditioning Research, 25 (12), 3461-3471