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The cleanest experiment is to discontinue and see if the symptom resolves

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Subcutaneous injections of 250 g/kg body weight were delivered into the male wistar rats, resulting in an insulin secretion assay that demonstrates anti-diabetic characteristics through the activation of GLP-1 receptor agonists

10.1016/j.lfs.2020.118627 236 KhanM

By then, the recycling system has likely been running on empty for a while