Since GAD is a cytosolic enzyme ( Figure 3 Metabolic pathways for degradation of glutamate and GABA While the primary event responsible for inactivation of the neurotransmitter action of glutamate and GABA is related to the high-affinity transporters for these amino acids, the subsequent intracellular metabolic pathways for degradation of glutamate and GABA are of functional significance [Ref
In this phenomenon, intramyocellular fat, which accounts for approximately 1.5% in healthy individuals, can rise to 5% in obesity and up to 11% with aging [80]
PMID: 36079838
doi: 10.3389/fphar.2024.1483792 Received 20 August 2024 Accepted 23 December 2024 Published 20 January 2025 Volume 15 - 2024 Edited by Ewa Krystyna Szczepanska-Sadowska, Medical University of Warsaw, Poland Reviewed by Per M
Until then, we can only speculate based on the current understanding of how semaglutide works in other conditions
However, it can occasionally be chronic