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15 Connection to Sleep : The gut-brain axis, a bidirectional communication system between the gastrointestinal system and the brain, plays a surprising role in sleep regulation

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The majority of effects seen upon DPP4-inhibitor treatment are ascribed to an increase in GLP-1 levels

We performed functional enrichment analysis on the identified sub-networks to further clarify the role of these potential complexes in life regulation

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Intranasal bioavailability to the CNS is estimated at 1-3% of the administered dose low in absolute terms but sufficient for pharmacological effect because the target tissue (brain) receives drug directly without first-pass hepatic metabolism