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Even if a fragment survives, the intestinal epithelium is a selective barrier: peptides above roughly 500 to 700 daltons struggle to cross via paracellular routes, and transcellular uptake is limited to specific transporter substrates
doi: 10.1002/jcp.28126 289 YangZLinSDZhanFLiuYZhanYW
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During breakthrough infection after vaccination, T-cell and plasmablast activation occur rapidly, while nAb and memory B-cell activation occurs ~2 weeks postinfection
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