Vitamin B12 functions as a cofactor for two essential enzymes: methionine synthase (involved in homocysteine metabolism and DNA synthesis) and methylmalonyl-CoA mutase (crucial for fatty acid and amino acid metabolism)
Overall, a number of studies have investigated the effects of micronutrients such as vitamins, sulphur-containing amino acids, antioxidants, and essential minerals on kinetics and adverse effects of toxic elements [6468]
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Wymann MP, Schneiter R
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The combination of autophagosome isolation and quantitative proteomics has identified nuclear receptor coactivator 4 (NCOA4) as the cargo receptor responsible for autophagy-dependent ferritin degradation (52)