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Yes, Rybelsus (semaglutide) can cause diarrhoea as a recognised side effect

CYP1A2 gene variants influence how quickly the body processes caffeine, while GLP-1R genetic variants affect receptor density and response intensity

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While you might get a slight dopamine spike after your non-nutritional nosh, it won't last

10.1016/S0301-0082(98)00075-6 McNamara JO: Drugs effective in the therapy of the epilepsies

Regarding rosiglitazone, RCTs demonstrated a biochemical improvement in liver enzymes and glycemic control both in diabetic and non-diabetic patients with NAFLD, whereas evidence of histological improvement is less clear: results derived from different studies are controversial regarding the effect on steatosis, ballooning, and fibrosis [45, 46, 57, 58]