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A higher degree of overlap suggests that the synthesized evidence in umbrella reviews is predominantly derived from multiple review studies that rely extensively on the same primary studies (23)

Selank: Intranasal administration at 300 to 600 mcg one to two times daily

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Comorbidities such as cardiovascular disease, sleep apnea, or uncontrolled diabetes change priorities: reduce hypoglycemia risk, avoid volume depletion, and maintain glycemic targets that fit the procedures risk profile