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Adequate hydration (at least 2-3 liters daily), fiber supplementation, and magnesium citrate at bedtime are the first-line approaches

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However, the existence of hypoxia and necrosis also provides an opportunity for tumour-selective therapy, including prodrugs activated by hypoxia, hypoxia-specific gene therapy, targeting the hypoxia-inducible factor 1 transcription factor, and recombinant anaerobic bacteria

This information is provided for educational purposes only and does not constitute medical advice or a guarantee of therapeutic benefit