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Retatrutide is being studied as a triple agonist, while tirzepatide is an approved dual agonist for certain indications

Post-meal pharmacodynamic profile of AVE0010, a once-daily GLP-1 receptor agonist, in patients with type 2 diabetes inadequately controlled on metformin [abstract 131]

Biochem Biophys Res Commun 2016;476:196-203.ArticlePubMed 34

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They simply reveal structural changes that were already occurring beneath the surface

30, 2026 An earlier version of this story mistakenly said that the drug tirzepatide blocks a hormone called GIP